Dr. Malcolm John VandenBurg - CV


D.O.B. 21.12.48


Dr Malcolm Vandenburg is a Specialist in General and Pharmaceutical Medicine.


He is available to give medico-legal expert witness reports and appear as a medico legal expert witness and supply medical written expert opinions in any matters referred to on this page.


Click to Download CV as PDF



BSc Upper 2nd Class Hons. Physiology
(Cardio-Respiratory, Neurological & Radiation Biology)
MBBS, St Bartholomew's Hospital 1974
MRCP 1976
Joint Committee on Higher Medical Training Certificate
in General (Internal) Medicine
Fellow, American College of Clinical Pharmacology 1991
Fellow, Faculty of Pharmaceutical Medicine 1993
Fellow, Royal College of Physicians 1996
Member International Stress Management Association 1998
GMC Specialist Recognition in General Internal Medicine 2004
Law Society Approved Expert Witness 2004
Registered: UK National Crime Operations Faculty 2004
National Police Improvement Agency Expert Adviser Database 2009


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1. Established a private practice in sexual health, general medicine, affective disorder and clinical pharmacology.
2. Established a medico-legal practice and pharmaceutical consultancy
3. Registered with GMC as Specialist in General(Internal) Medicine.
4. Founded the London Hospital Hypertension Clinic in 1975 and performed many phase I, II and III studies on anti-hypertensive compounds.
5. Over 300 publications and research communications.
6. Founded, supported and managed Romford Cardiovascular Research, a cardiovascular clinical research organisation based at Old Church Hospital, Romford. Trust fund of £300,000 transfered to NHS 2007.
7. Original member of Merck & Co Worldwide Global Integrated Drug Development Management Committee.
8. Founded a clinical research consultancy and managed its growth from two people in a portakabin to 150 people in four European centres, South Africa, Australia and the USA.
9. Negotiated the sale of the company to a Japanese public company.
10. Managed the resulting global clinical research organisation of 500 people with a turnover of £40 million.
11. Helped negotiate the sale of the company to a Canadian public company.
12. Responsible for the worldwide registration of four pharmaceutical medicines and the registration of 30 medicines in UK and Europe.
13. Developed a management training company centred on the pharmaceutical industry, running skills and personal development workshops with a turnover of £1 million.
14. Started and negotiated the sale of a clinical pathology company with a turnover of £300,000.
15. Appointed as founder member of Europe's 500, a foundation sponsored by the European Commission and Earnst and Young, to identify Europe's top entrepreneurs and job creators.
16. Wrote the book Positive Under Pressure with Gael Lindenfield published by Thorsons.
17. Supervised Positive Under Pressure workshops for 3,000 UK General Practitioners.
18. Founded Consultrum (2002) a psychiatric clinical research organisation, a pharmaceutical consultancy and a legal consultancy.
19. Dad to four wonderful children and two dogs named Will and Duffy.

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1. Physician: I am currently working as a Physician seeing patients referred to me by General Practitioners and other doctors within my areas of expertise, primarily general medicine, sexual health and affective disorders and clinical pharmacology.
2. Medico-legal Expert Witness: providing opinions for the Court and advising the legal profession in the fields of prescription medicines, illegal drugs, general internal medicine and sexual health. Instructions have been received from solicitors, barristers, Crown Prosecution Services, Police Forces, the Armed
Forces, the Police Federation and legal consultancies.
3. Founder and Director of Positive Under Pressure™:Positive Under Pressure™ is a pressure management company which assists individuals, groups, organisations and Government agencies identify and modify
their responses to pressure, so that they gain the benefits of enhanced performance without the negative impact of stress, and addictive coping strategies.

The techniques used in Positive Under Pressure™ have now proven useful to over seventy five groups of General Practitioners who use the techniques to modify their own stress levels as well as teaching the techniques to their patients.
Seminars have been performed for The Royal College of General Practitioners, The Royal Society of Medicine, The Royal Defence Medical College and the Royal Navy. Training programmes have also been run at The Royal College of Psychiatrists.

The book Positive Under Pressure is published by Thorsons
4. Pharmaceutical Consultancy: I offer advice to the Pharmaceutical, Biotechnology and Healthcare industries. I advise on both business development and registration of pharmaceutical products and medical devices. The clinical development programmes I have been responsible for are attached.


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1. Psychiatric Clinical Investigator: I worked with Dr Cosmo Hallström, Consultant Psychiatrist, at the Capio Nightingale Clinic Chelsea, performing psychiatric clinical studies. These include studies in depression, anxiety and panic.
2. Director of Same Day Doctor: A private medical clinic comprising medical, sexual and psychological clinics in Harley Street, employing three doctors, two nurses, two practice managers, three administrators and additional staff as needed.
3. Editor-in-Chief: of Dilemmas and Solutions in Global Drug Development, PJB Publications.
4. Parents Under Pressure: I was responsible for the parent support groups at the Capio Nightingale Adolescent Mental Health Unit at Radnor Walk, Chelsea, supporting parents through the stress of having their children admitted to this hospital and having mental health problems.
5. Honorary Clinical Assistant: In Renal Medicine to Professor John Cunningham, The Middlesex and University College London.

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Locum House Physician to Drs Black and Dawson in General Medicine &
Gastroenterology, St Bartholomews Hospital
Jul 1973 – Sept 1973
House Surgeon,to Mr Page, Paine and Devereux, Urology, Vascular &
General Surgery, North Middlesex Hospital
Oct 1973 – Mar 1974
House Physician, to Dr Hayward, Wykehan-Balme & Spurrell, General Medicine,
Cardiology & Rheumatology, St Bartholomew's Hospital.
Apr 1974 – Sep 1974


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Senior House Officer in General Medicine, The London Hospital, Whitechapel
Senior House Officer in Accident & Emergency
Senior House Officer in Venerology to Dr Ambrose King
Senior House Officer in General Medicine & Gastroenterology to Dr Wright
Senior House Officer in General Medicine and Respiratory Medicine
to Drs Hughes and Hickman
Oct 1974 – Dec 1975


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Lecturer in Medicine, the London Hospital, Whitechapel on the Medical Unit,
Director, Professor Ledingham.
1976 - 1980
Honorary Registrar in General Medicine to Prof Ledingham and sexual health
to Drs Dunlop and Rodin
.. All medical unit positions gave experience as the most
senior doctor on the unit during 'admission takes' for the firm. The unit was on
'take' 1/5 and 1 weekend in 5. When the NHS position was as an Honorary
Registrar, there was no senior registrar on call. Cover was provided to all other
Junior staff at the hospital. Clinics were two general medical clinics a week for
Prof Ledingham and Prof. Floyer and either an Endocrinology clinic for Prof
Cohen or a nephrology clinic for Dr Goodwin or Marsh. A clinic in sexual health
was continued and patients were managed on the wards.
Jan 1976 – Jun 1976
Honorary Registrar in Cardiology to Dr Wallace- Brigden and Alistair MacDonald.
Experience involved training in left and right ventricular cathetrisiton M mode and
later 2D echocardiography, pacemaker implantation both permanent and
temporary, and ahrythmia assessment.
There were three cardiology clinics a week and a general medical clinic was
continued. Additional experience was obtained in being responsible to the
consultant for the running of the coronary care unit and cardiac doctor on call on a
1 in 4 rota.
Jul 1976 – Dec 1976
Honorary Registrar in Medicine to Prof Mike Floyer. Experience as before.
In addition I was prime mover in establishing the London Hospital Hypertension
Clinic under the guidance of Professor J M Ledingham. My responsibilities
included staffing and funding the Unit, and I was involved in prioritising research
within it. The clinic had both a service and a research commitment. I advised
general physicians on the management and investigations of hypertensive patients,
as well as having referrals direct from general practice. The research carried out in
the clinic forms the basis of many of my publications.
A screening programme was established in general practice to identify patients
with high blood pressure. Advice and guidance were obtained from Prof. Colin
Dollery (Hammersmith Hospital) and Professor Robertson (MRC Blood Pressure
Unit, Glasgow) in the establishment of such programmes as well as the
management of specialist hypertension units. The London Hospital Clinic was one
of the first in the UK.

Honorary Senior Registrar in General Medicine to Profs Ledingham, Floyer and

There was continuous research and teaching experience. During this period there
was a rotation of six months of general medicine and six months of additional
I continued to manage and run the London Hospital Hypertension Clinic during
this time. It consisted of a technician, a research sister and a secretary, all self
funded from research grants I obtained.
Other Lecturers in Medicine used the clinic for their experience and research. I
remained responsible to Prof Ledingham for the clinical care of patients.

I had three periods on the wards being responsible to the consultant for the clinical
care of patients (experience as before).
I had two further periods of attachment to the Cardiology Department (experience
as before).
There was an additional six months attachment to the Renal Unit, being
responsible to Drs Goodwin and Marsh, where my experience included, renal in
patient and out patient care, pre and post dialysis care, as well as the care of pre
and post transplantation patients. Further endocrinology experience was obtained
with Professor Cohen.

1977 - 1980

Honorary Lecturer in Medicine, The London Hospital.
On leaving the Medical Unit, I joined MSD (see later). I continued with my
responsibility to fund and manage the Hypertension Clinic responsible to Prof
Cohen, in the position of Honorary Lecturer in Medicine on the retirement of Prof
Ledingham. The management of the unit was taken over by Dr Goodwin when I
left MSD.

Publications resulting from my work at the London Hospital can be found
throughout my publications on the PubMed List attached. They are numbers 35,
52 and 56-57 and 59-71.

My research on the unit included:
1. Effects of beta blocking drugs on the peripheral circulation
2. Treatment of resistant hypertension
3. Converting enzyme inhibitors and inhibition in the treatment of hypertension
and the physiological responses to stress

1981 - 1985

Honorary Lecturer in Clinical Pharmacology to Prof Paul Turner, Professor of
Clinical Pharmacology, St Bartholomew's Hospital
Experience included an out patient clinic in general medicine and clinical
pharmacology as well as a research clinic.

I studied the effects of converting enzyme inhibitors on plasma neuropeptides in
conjunction with Professor Lesley Rees, Professor of Chemical Pathology, St
Bartholomew's Hospital, in patients with hypertension and heart failure and in
patients on non-steroidal anti-inflammatory agents.

These papers can be found in my full Publications List and in the PubMed list
paper numbers 45 and 50.

Director and Co-ordinator of Cardiovascular Research, Old Church Hospital,
Romford, Essex.

In conjunction with Dr Stephens, I established a research charity in this District
General Hospital, undertaking studies in cardiovascular disease. There were five
clinics a week, one each in Hypertension, Angina, Heart Failure, Ahrhythmias and
Emergency Referrals. I also attended two NHS clinics in General Cardiology. The
unit undertook ½ the NHS workload at the hospital.
The publications resulting from this work in the unit are throughout my
Publications Lists.
1985 - 1995
Director and Trustee of Romford Cardiovascular Research
I have been a Director and Trustee of the Unit which was handed over to the NHS
in June 2003. The research funds were donated to the NHS trust in November
1996 - 2003


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Throughout employment at the London Hospital and Merck Sharp & Dohme, I was formally involved in the teaching of both medical students and junior hospital doctors studying for
their M R C P.

I organised the London Hospital MRCP Tutorial Scheme. I organised the MRCP
examinations on three occasions.

I was a member of:
* The London Hospital Medical College Education Committee.
* London Hospital Division of Medicine Working Party on
Postgraduate Education.
* Chairman of the Tower Hamlets Junior Hospital Staff Committee.
* Junior Hospital Staff Representative - Division of Medicine and Final Medical

1977 - 1987


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Director of Clinical Research, Merck Sharp & Dohme
I was responsible for all MSD's clinical research in the United Kingdom, which
involved a clinical commitment to cardiovascular disease, rheumatological
disease, gastroenterological disease and antibiotic therapy and many other
therapeutic classes.

While directing this research programme, members of my department had a total
of over 100 publications and presentations. The research programme resulted in
over three times this number of communications of research. I was involved in
approximately 600 clinical research studies spanning the complete spectrum of
pharmacological research from Phase I to Phase IV.

I developed a strategy that all research performed by the Company should be of a
sufficiently high standard to stand peer review and even the Company's multi
centre GP studies were presented at major UK scientific societies.

I continued with attachments at two London teaching hospitals throughout my
career within the pharmaceutical industry.

I was responsible for the UK development of Enalapril, a converting enzyme

I was responsible for the Phase III development of Norfloxacin, a urinary
antibiotic, Imipenem, a broad spectrum antibiotic and Indocid Gel, a topical
preparation of Indomethacin, and Famotidin, an H2 antagonist and Simvastatin a
lipid lowering agent.

Phase II and II programmes were supervised for anti-depressants,
bronchodilatators, mast cell stabilisers and antiarrhythmics.

In addition, research programmes included those for cardiovascular drugs -
Aldomet, Moduretic, Blocadren, Amiloride and Moducren, ophthalmic drugs,
particularly Timoptol, anti-rheumatic drugs, such as Indomethacin, Indocid and
Clinoril and Osmosin, anti-infectives.

I also developed with Merck Sharp & Dohme the concept of sponsorship for
academic research which had a corporate interest. The most successful of these
projects was the programme to investigate the relationship between a lowered
serum potassium and the occurrence of arrhythmias. This work is often quoted
and has played a major part in developing the hypothesis out- lined above. Staff -
five physicians, seven CRAs and secretaries.

1981 - 1985


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Chief Executive Officer, ROSTRUM Group Limited
I was Chairman and founder of MCRC Group Limited, which changed its name to
ROSTRUM in 1994, the international contract research organisation with offices
in the UK, USA, France, Germany, Italy, South Africa and Australia.

I established MCRC as a leading European contract research and consultancy
organisation and have established research units at many hospitals. The
Company, under my direction, has successfully handled research, registration and
statistical projects for most of the major American and European pharmaceutical
companies. I have personally supervised clinical expert reports, which have led
to the registration of many drugs in the areas of hypertension, heart failure,
angina, arrhythmias, antibiotics, urology, oncology and respiratory medicine, as
well as many others.

I also founded and developed ROSTRUM, an organisation which trains in
research and regulatory skills, personal development programmes, and organises
many international conferences.

I have lectured widely and taught for major innovative pharmaceutical companies
on GCP and drug development throughout Europe as well as in the Near East, Far
East and South American countries. I consistently presented original research at
major international and national scientific meetings, as well as publishing articles
on many subjects at the rate of twenty per year. I co-authored "GCP for
Investigators" which has sold over 40,000 copies in English, Spanish, German,
French, Italian and Russian.

1986 - 1995

President and CEO, IBRD-ROSTRUM GLOBAL, a multi-national clinical
Research organisation serving the pharmaceutical industry. It employed 500
people, with major offices in California, Philadelphia, London and across Europe.
The turnover was appropriate for a company of this size within the CRO sector.
My direct reports were the Senior Vice President, Finance, the Senior Vice
Presidents for Operations in the USA and Europe, and the Senior Vice Presidents
for Sales and Medical Affairs.

I was responsible to the Board of Kuraya, a Japanese company, for the scientific
performance of the global company. I continued with scientific input and
consultancy activities. My most notable scientific achievement was completing
the filing of a complete NDA for a Japanese client for an anti epileptic.

I have successfully completed Phase III programmes for anti-hypertensives and
anti-infectives, Phase I programmes for insulin sensitisers and disease modifying
drugs in rheumatoid arthritis, and Phase II programmes in heart failure and insulin
sensitising drugs.

I was responsible for the registration of four medicines worldwide: an
antiarrhythmics, an hypnotic, an anti-epileptic and an anti-biotic.

I registered 30 other medicines in the UK and Europe including an anaesthetic, an
anti-cancer agent, an anti-emetic, ereutho proetin and urological products as well
as many other cardio vascular and anti infective compounds.

Pharmacoepidemiological studies on non-steroidal anti inflammatory drugs and
the gastro intestinal system, H2 antagonists and malignancy, cardiac safety of
drugs for erectile dysfunction, asthma and many other classes of compounds.

1995 - 1998


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Editor: St Bartholomew's Hospital Journal, 1970 – 1971
Managing Director: St Bartholomew's Hospital Journal, 1972 - 1974
Member: Organising Committee of Bartholomew Fair, the Festival celebrating St
Bartholomew's Hospital 850th anniversary.
Chairman, the London Hospital Silver Jubilee Festival Committee, 1977
Senior Management Programme Ashridge Management College.
European School of Business Administration, Senior Managers MBA Programme
INCEAD, Fontainebleau.
Author: Positive Under Pressure, Published by Thorsons.
Author: Good Clinical Practice for Investigators.
Author: Standard Operating Procedures for Investigators.
Editorial Board: Journal of Good Clinical Practice.
Editorial Board: Applied clinical Trials Journal.
Reviewer: British Journal of British Pharmacology.
Reviewer: Journal of Human Hypertension.
Editor-in-Chief: Dilemmas and Solutions in Global Drug Development, PJB



Clinical Investigator

* Good knowledge of the clinical trial process and GCP.
* Friendly, reassuring attitude to patients to build good relationships and confidence.
* Ability to network with General Practitioners to reassure them of their patient's safety and to gain their cooperation in the clinical trial process.
* An in-depth knowledge of pharmaceutical medicine helps put safety concerns into a clinical perspective.
* Founded the London Hospital Hypertension Clinic in 1975 and performed many phase I, II and III studies on anti-hypertensive compounds.
* Honorary Physician, Department of Clinical Pharmacology at St Bartholomew's Hospital, 1980 – 1984. Performed Phase I, II and III Studies anti-hypertensive compounds.
* 1984 to 2003 responsible for clinical research within the Department of Cardiology at Oldchurch Hospital and have performed over 60 studies in all aspects of cardiovascular disease.

Pharmaceutical Physician
* Broad range of therapeutic knowledge and contact with opinion leaders
* Able to collect and critically analyse data and information from the company literature, searches and academics, to construct the best critical path for product development and registration
* Co-ordinating author of 30 clinical expert reports in cardiovascular, CNS, antibiotic and many other therapeutic areas.
* Leader of crisis management team in support of four products.
* Networking and influencing abilities enabling the distillation of divergent opinions from regulators and consultants across national boundaries to develop plans in line with the company's strategy which are endorsed by these critical groups
* Sound track record of developing practical clinical operation plans with critical go/no-go decision points, especially fast track 2A studies
* An ability to get research presented and published for key meetings and journals. I have over 75 peer-reviewed articles and a larger number of presentations, many in conjunction with leading experts in the fields of my interest.
Below, I list a few of the comments made about me by a Human Resource Director,
of one of my major clients:

* 'Excellent communications skills'
* 'Strategic thinker – not entrenched in the now or the past'
* 'Proven commercial acumen and ability'
* 'Commercial experience in environments of rapid growth and change'
* 'Intellectual agility and stamina'
* 'Visionary – not necessarily detail conscious, but able to view the wider picture and associated issues'
* 'Technical knowledge'
* 'The ability to distil issues, quickly and concisely, resulting in identification of pertinent points and required action'
* 'Outcome focused'
* 'Influencing abilities'
* 'Networker'
* 'A contributor of ideas – an active participant in meetings'
* 'Willingness and ability to challenge the status quo, leading to positive outcome/solution'
* 'Persuasive'
* 'Financially aware/competent'


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These are shown on the attached list and are grouped according to my areas of interest and available on request:


Recent Publications:
1997 Editorial Articles
Effects of Hypertensive Drugs on Peripheral Vascular Physiology
Converting Enzyme Inhibition
Case Reports
General Medical Topics
Hypertension General
Effect of Potassium on Arrhythmias
Effect of Potassium on Hypertension
Clinical Studies on Moducren
Triple Therapy for Hypertension
Research Methodology
Good Clinical Practice
Isosorbide Mononitrate in Heart Failure
Quality of Life
Angina Studies
Press Releases
Advisory Boards & Academic Reviews

Personal Development
Positive Under Pressure


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The Sunday Times Personal Development Show JUNE 1997
The Sunday Times Personal Development Show JUNE 1998
The Royal Society of Medicine JUNE 1998
Institute of Personnel & Development OCT 1999
Mind, Media & Medicine MAY 2000
The Human Resources Forum MAY 2000
* The Royal Society of Medicine
* The Royal College of General Practitioners
* The Royal College of Psychiatrists
* Royal Defence Medical College
* The Royal Navy
* HM Treasury
* University of Wales
* Association of Accounting Technicians
* Pfizer
* Pharmacia
* International Business Communications
* 60 seminars have been performed for local GP Tutors as part of refresher courses, study days or weekly
* 10 seminars have been performed for Human Resource Departments in the Healthcare sector
* 5 seminars have been performed for NHS Trusts
* University of Portsmouth
* Personal Development Training
Pharmaceutical Times, September 1994, p26-27
* Self Confidence for Success
Pharmaceutical Marketing, September 1994, p41-42
* 5 Rs for Keeping Positive Under Pressure
Business Now, August 1997, issue 94
* Positive Under Pressure
Training Officer, December 1998, Vol 34 No 10, p303-305
* Grace Under Pressure
Sales Director, November 1998, p63
* Is your job a health hazard?
Health & Fitness, May 2000, p51
* Be Positive Under Pressure
Business Executive, Winter 2000, p6-8
* The Stress-free Life Plan
Family Circle, November 2001, p58 – 60
* Coping with Stress
BMA News, March 1999
* I want to Dive into Life Now, Not Push it Away
Zest, May 1999
* Tackle Stress Before it Tackles You
The Times, June 1999, p3
* Overworked, Over Stressed, Over Here
The Independent on Sunday, August 1999, p9
* Health Report – The Working Weak
The Observer Magazine, February 2000 p17
* Expert Tips for Time Management
The Sunday Times, March 2000, p4
* Positive under pressure
Sunday Express, June 2000
* How your body reacts when you get dumped
The Mirror, July 2000
* Off work again, eh?
Real Business, July/August 2000
* From stress to serenity
Here's Health, July 2000, p44
* How are you coping with pressure?
New Impact, August 2000, Issue 6 Vol 6
* Health Report
Observer Magazine, September 2000
* Take control of your health
Home & Life, October 2000
* Ready to relax
Accounting Technician, October 2000
* Are you hooked on being busy?
Woman's Weekly, November 2000, p22
* How to pick up early signs of stress
The Observer, 12 November 2000
* How to avoid suffering from stress
The Observer, 19 November 2000
* How to deal with stressed-out colleagues
The Observer, 26 November 2000
* Your Body
The Mirror, November 2000
* Occupational Hazards
Shape, January/February 2001
* Hurry Sickness
Daily Express, August 2001
* The Break-up Body
Daily Mail, 17 September 2001, p42-43
* What Type of Eater Are You
Daily Express (ExpressWoman), 20 August 2002, p32-33
* I Juggle Too Much
Woman, 10 February 2003, p29
* Winning at the Career Game
Institute of Directors Central London Newsletter, Oct 1994
Institute of Directors Central London Newsletter, Jan 1995
* Positive Under Pressure Luncheon
Mossimann's newsletter, October 1995
* Thriving on pressure
Training Update, July 1998
* Manual Labour
Daily Express, May 2000
* Book Review
People Management, June 2000
* Preview, latest books, tapes & events
Health & Fitness, July 2000
* Three of a kind… stressbusters and pressure points
Management Today, July 2000
* Bookshelf - new books that might change your life
Zest, July 2000
* Positive Under Pressure
Pharmaceutical Physician, September 2000, Vol 11 No 2
* Family doctors 'taking on too much'
Stafford Express & Star, 30th April 2001
Wolverhampton Express & Star, 30th April 2001
Kidderminster Express & Star, 30th April 2001
Dudley Express & Star, 30th April 2001
Lichfield & Burntwood Express & Star, 30th April 2001
Walsall Express & Star, 30th April 2001
Cannock Express & Star, 30th April 2001
* GPs 'taking on too much work'
Evening Telegraph & Post (Dundee), 30th April 2001
* 'System relies on workaholics', says expert
The News (Portsmouth) 30th April 2001
* Question mark over the effect of GPs' protest
Newcastle upon Tyne Journal, 30th April 2001
* Workaholic GPs are a suitable case for stress treatment
Birmingham Post, 30th April 2001
* Family doctors take on too much work, says expert
Western Mail (Cardiff), 30th April 2001
* Over-stressed GPs 'taking on too much work'
PA News, 30th April 2001
* Expert says GPs are now learning to deal with stress
General Practitioner, May 2001
* Maximising your potential
Clinical Research Focus, Vol 6, No 3
* El Estres Me Sienta Bien
Tercera, Chilean Newspaper 27 December 2002
* Friend or Foe? (Men's Health)
netdoctor.co.uk, January 2000
* Christmas Advice
icommerce.ie, December 2000
* Saying 'No' helps GPs' stress
doctorsworld.com, April 2001
* GPs shut surgeries over workloads
ITN.co.uk/news, June 2001
* Stressbusting's guide to what to read and listen to now
* Good times, bad times - stress in the good old days
* Work Pressure – Can you handle it?
topjobs.co.uk – instant expert article


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1: Andrews D, Gouda MS, Higgins S, Johnson P, Williams A, Vandenburg M.
A comparative study of a new wireless continuous cardiorespiratory monitor for
the diagnosis and management of patients with congestive heart failure at home.
J Telemed Telecare. 2002;8 Suppl 2:101-3. Erratum in: J Telemed Telecare.
PMID: 12217157 [PubMed - indexed for MEDLINE]

2: Johnson P, Andrews DC, Wells S, de Lusignan S, Robinson J, Vandenburg M.
The use of a new continuous wireless cardiorespiratory telemonitoring system by
elderly patients at home.
J Telemed Telecare. 2001;7 Suppl 1:76-7.
PMID: 11576502 [PubMed - indexed for MEDLINE]

3: Dews I, VandenBurg M.
A 24-week dose-titration study of the angiotensin-converting enzyme inhibitor
imidapril in the treatment of mild-to-moderate essential hypertension in the
J Int Med Res. 2001 Mar-Apr;29(2):100-7.
PMID: 11393342 [PubMed - indexed for MEDLINE]

4: de Lusignan S, Althans A, Wells S, Johnson P, Vandenburg M, Robinson J.
A pilot study of radiotelemetry for continuous cardiopulmonary monitoring of
patients at home.
J Telemed Telecare. 2000;6 Suppl 1:S119-22.
PMID: 10793994 [PubMed - indexed for MEDLINE]

5: La Puma J, Stocking CB, Rhoades WD, Darling CM, Ferner RE, Neuberger J, VandenBurg M, Dews I, Tobias JS.
Financial ties as part of informed consent to postmarketing research. Attitudes
of American doctors and patients.
BMJ. 1995 Jun 24;310(6995):1660-3. Erratum in: BMJ 1995 Aug 5;311(7001):373.
PMID: 7795459 [PubMed - indexed for MEDLINE]

6: Vandenburg M.
Postmarketing surveillance. Is not used to promote products.
BMJ. 1994 Sep 3;309(6954):608. No abstract available.
PMID: 8086968 [PubMed - indexed for MEDLINE]

7: Vandenburg MJ, Mackay EM, Dews I, Pullan T, Brugier S.
Dose finding studies with imidapril--a new ACE inhibitor.
Br J Clin Pharmacol. 1994 Mar;37(3):265-72.
PMID: 8198936 [PubMed - indexed for MEDLINE]

8: Vandenburg MJ, Allen ME.
Good clinical practice--a question of balance.
Br J Clin Pharmacol. 1994 Jan;37(1):101-2. No abstract available.
PMID: 8148212 [PubMed - indexed for MEDLINE]

9: Walley T, Tsao Y, Scott A, Mackay E, Vandenburg M, Breckenridge A.
Effects of dilevalol (R,R-labetalol) compared with nifedipine on heart rate,
blood pressure and muscle blood flow at rest and on exercise in hypertensive
Br J Clin Pharmacol. 1993 Jun;35(6):623-8.
PMID: 8329290 [PubMed - indexed for MEDLINE]
10: Vandenburg MJ, Stephens JD, Resplandy G, Dews IM, Robinson J, Desche P.
Digoxin pharmacokinetics and perindopril in heart failure patients.
J Clin Pharmacol. 1993 Feb;33(2):146-9.
PMID: 8440763 [PubMed - indexed for MEDLINE]

11: Allen ME, Vandenburg MJ.
Good clinical practice: rules, regulations and their impact on the
Br J Clin Pharmacol. 1992 May;33(5):463-5. No abstract available.
PMID: 1524957 [PubMed - indexed for MEDLINE]

12: Foale RA, Vandenburg MJ.
Sustained-release verapamil and nifedipine in exercise-induced angina pectoris.
Eur Heart J. 1992 Feb;13(2):256-60.
PMID: 1555625 [PubMed - indexed for MEDLINE]

13: Wight LJ, VandenBurg MJ, Potter CE, Freeth CJ.
A large scale comparative study in general practice with nitroglycerin spray
and tablet formulations in elderly patients with angina pectoris.
Eur J Clin Pharmacol. 1992;42(3):341-2.
PMID: 1577055 [PubMed - indexed for MEDLINE]

14: Sennesael J, Ali A, Sweny P, Vandenburg M, Slovic D, Dratwa M, Resplandy G, Genissel P, Desche P.
The pharmacokinetics of perindopril and its effects on serum angiotensin
converting enzyme activity in hypertensive patients with chronic renal failure.
Br J Clin Pharmacol. 1992 Jan;33(1):93-9.
PMID: 1311597 [PubMed - indexed for MEDLINE]

15: Dews IM, VandenBurg MJ, Pullan TR.
A randomized crossover study of the blood pressure effects of tobacco and
non-tobacco cigarettes.
J Hypertens Suppl. 1991 Dec;9(6):S120-1. No abstract available.
PMID: 1818907 [PubMed - indexed for MEDLINE]

16: Robinson P, Vandenburg M, Dews I.
Informed consent.
BMJ. 1991 Nov 2;303(6810):1138. No abstract available.
PMID: 1747598 [PubMed - indexed for MEDLINE]

17: Dews IM, Vandenburg MJ.
Preventing fraud.
BMJ. 1991 Apr 13;302(6781):907. No abstract available.
PMID: 1859564 [PubMed - indexed for MEDLINE]

18: Hyer SL, Kohner EM, Davies G, Mackay EM, VandenBurg MJ.
Effects of dilevalol, propranolol and placebo on retinal blood flow, blood
pressure and heart rate: a double-blind study.
J Hum Hypertens. 1990 Jun;4 Suppl 2:63. No abstract available.
PMID: 2196370 [PubMed - indexed for MEDLINE]

19: Wight LJ, Potter CE, Vandenburg MJ, Brandman S.
Experience with Nitrolingual spray in general practice.
Br J Clin Pract. 1990 Feb;44(2):55-7. No abstract available.
PMID: 2116820 [PubMed - indexed for MEDLINE]

20: Marks C, Dews I, Gould SE, Stephens J, VandenBurg M.
The effects of ketanserin on ventricular ectopic activity in humans.
Cardiovasc Drugs Ther. 1990 Jan;4 Suppl 1:93-5.
PMID: 2285656 [PubMed - indexed for MEDLINE]

21: Dews I, Wiseman WT, al-Khawaja I, Stephens J, VandenBurg M.
A comparison of single doses of lisinopril and enalapril in hypertension.
J Hum Hypertens. 1989 Jun;3 Suppl 1:35-9.
PMID: 2550644 [PubMed - indexed for MEDLINE]

22: Ritchie LD, Harrington LT, MacGregor AR, Vandenburg MJ.
Nifedipine as low-dose monotherapy for essential hypertension: a primary care
Cardiovasc Drugs Ther. 1989 Jun;3 Suppl 1:341. No abstract available.
PMID: 2487805 [PubMed - indexed for MEDLINE]

23: Vandenburg MJ, Morris F, Marks C, Kelly JG, Dews IM, Stephens JD.
A study of the potential pharmacokinetic interaction of lisinopril and digoxin
in normal volunteers.
Xenobiotica. 1988 Oct;18(10):1179-84.
PMID: 2853897 [PubMed - indexed for MEDLINE]

24: Debbas N, Woodings D, Marks C, Bhans A, Jubber A, Dews I, Stephens J, Vandenburg M.
Dose-ranging study of isosorbide-5-mononitrate in chronic congestive heart
failure treated with diuretics and angiotensin-converting enzyme inhibitor.
Am J Cardiol. 1988 Mar 25;61(9):28E-30E.
PMID: 2831702 [PubMed - indexed for MEDLINE]

25: Wight LJ, Vandenburg MJ, Griffiths GK, Gudgeon AC, Kelsey M.
An assessment of the clinical efficacy in general practice of cefuroxime axetil
when used in the management of unidentified infections of the lower respiratory
Br J Clin Pract. 1987 Nov;41(11):991-4. No abstract available.
PMID: 3504320 [PubMed - indexed for MEDLINE]

26: Gudgeon AC, Vandenburg MJ, Wight LJ, Griffiths GK, Kelsey M.
Is oral cefuroxime axetil suitable for the treatment of unidentified bacterial
infection of skin and soft tissue?
Br J Clin Pract. 1987 Oct;41(10):954-6. No abstract available.
PMID: 3505179 [PubMed - indexed for MEDLINE]

27: Griffiths GK, VandenBurg MJ, Wight LJ, Gudgeon AC, Kelsey M.
Efficacy and tolerability of cefuroxime axetil in patients with upper
respiratory tract infections.
Curr Med Res Opin. 1987;10(8):555-61.
PMID: 3677790 [PubMed - indexed for MEDLINE]

28: Stephens JD, Marks C, Woodings D, Vandenburg MJ.
Acute and chronic use of isosorbide 5-mononitrate in patients with heart
Cardiology. 1987;74 Suppl 1:69-71. No abstract available.
PMID: 3607807 [PubMed - indexed for MEDLINE]

29: Vandenburg MJ, Wight LJ, Griffiths GK, Brandmann S.
Sublingual nitroglycerin or spray in the treatment of angina.
Br J Clin Pract. 1986 Dec;40(12):524-7. No abstract available.
PMID: 3115284 [PubMed - indexed for MEDLINE]

30: Mistry CD, Lote CJ, Currie WJ, Vandenburg M, Mallick NP.
Effects of sulindac on renal function and prostaglandin synthesis in patients
with moderate chronic renal insufficiency.
Clin Sci (Lond). 1986 May;70(5):501-5.
PMID: 3516534 [PubMed - indexed for MEDLINE]

31: Webster J, Petrie JC, Robb OJ, Trafford J, Burgess J, Richardson PJ, Davidson C, Fairhurst G, Vandenburg MJ, Cooper WD, et al.
Enalapril in moderate to severe hypertension: a comparison with atenolol.
Br J Clin Pharmacol. 1986 May;21(5):489-95.
PMID: 3013265 [PubMed - indexed for MEDLINE]

32: Kelly JG, Doyle G, Donohue J, Laher M, Vandenburg MJ, Currie WJ, Cooper WD.
Pharmacokinetics of enalapril in normal subjects and patients with renal
Br J Clin Pharmacol. 1986 Jan;21(1):63-9.
PMID: 3004546 [PubMed - indexed for MEDLINE]

33: Cooper WD, Doyle GD, Donohoe J, Laher M, Ledingham JG, Raine AE, Melinck C, Unsworth J, Raman GV, VandenBurg MJ, et al.
Enalapril in the treatment of hypertension associated with impaired renal
J Hypertens Suppl. 1985 Dec;3 Suppl 3:S471-4.
PMID: 2856770 [PubMed - indexed for MEDLINE]

34: Brandman S, Vandenburg MJ, Jenkins R, Currie WJ.
The effect of non-steroidal anti-inflammatory therapy on plasma neuropeptide
concentrations in patients with osteoarthritis.
Br J Rheumatol. 1985 Feb;24(1):46-52.
PMID: 3156655 [PubMed - indexed for MEDLINE]

35: Vandenburg MJ, Sharman VL, Drew P, Barnes J, Wright P.
Quadruple therapy for resistant hypertension.
Br J Clin Pract. 1985 Jan;39(1):17-9. No abstract available.
PMID: 3986093 [PubMed - indexed for MEDLINE]

36: Vandenburg MJ, Currie WJ, Mann SG, Diggins JB.
Differential effects of two non steroidal anti-inflammatory drugs on the plasma
urea of elderly patients with osteoarthritis. A multicentre study.
Br J Clin Pract. 1984 Nov-Dec;38(11-12):403-6. No abstract available.
PMID: 6397222 [PubMed - indexed for MEDLINE]

37: Vandenburg MJ, Currie WJ.
Mild hypokalaemia does appear to be associated with cardiac arrhythmias.
Practitioner. 1984 Sep;228(1395):777-9. No abstract available.
PMID: 6473284 [PubMed - indexed for MEDLINE]

38: Cooper WD, Kuan P, Reuben SR, VandenBurg MJ.
Cardiac arrhythmias following acute myocardial infarction: associations with
the serum potassium level and prior diuretic therapy.
Eur Heart J. 1984 Jun;5(6):464-9.
PMID: 6745288 [PubMed - indexed for MEDLINE]

39: Vandenburg MJ, Currie WJ, Cooper WD.
The use of a single combination tablet containing a beta blocker and a diuretic
in patients uncontrolled on either alone.
Br J Clin Pract. 1984 Jun;38(6):221-3. No abstract available.
PMID: 6743499 [PubMed - indexed for MEDLINE]

40: Currie WJ, Vandenburg MJ, Janke PG, Diggins JB.
Symptomatic osteoarthritis in the elderly: multicentre comparative study of
sulindac and ibuprofen.
Br J Clin Pract. 1984 May;38(5):176-81. No abstract available.
PMID: 6733011 [PubMed - indexed for MEDLINE]

41: Vogel R, Deaney NB, Round EM, VandenBurg MJ, Currie WJ.
Norfloxacin, amoxycillin, cotrimoxazole and nalidixic acid. A summary of 3-day
and 7-day therapy studies in the treatment of urinary tract infections.
J Antimicrob Chemother. 1984 May;13 Suppl B:113-20.
PMID: 6234271 [PubMed - indexed for MEDLINE]

42: Currie WJ, Vandenburg MJ, Cooper WD.
Do elderly patients respond differently to treatment with Moducren?
Br J Clin Pract. 1984 Mar;38(3):102-6, 119. No abstract available.
PMID: 6712874 [PubMed - indexed for MEDLINE]

43: Hayes TB, Fyvie A, Janke PG, Vandenburg MJ, Currie WJ.
Sulindac versus ibuprofen in sprains and strains.
Br J Sports Med. 1984 Mar;18(1):30-3.
PMID: 6372927 [PubMed - indexed for MEDLINE]

44: VandenBurg MJ, Cooper WD, Woollard ML, Currie WJ, Bowker CH.
Reduced peripheral vascular symptoms in elderly patients treated with
alpha-methyldopa--a comparison with propranolol.
Eur J Clin Pharmacol. 1984;26(3):325-9.
PMID: 6734693 [PubMed - indexed for MEDLINE]

45: Walker JW, VandenBurg MJ, Currie WJ.
Differential efficacy of two non-steroidal anti-inflammatory drugs in the
treatment of sports injuries.
Curr Med Res Opin. 1984;9(2):119-23.
PMID: 6544198 [PubMed - indexed for MEDLINE]

46: Vandenburg MJ, Evans SJ, Kelly BJ, Bradshaw F, Currie WJ, Cooper WD.
Factors affecting the reporting of symptoms by hypertensive patients.
Br J Clin Pharmacol. 1984;18 Suppl 2:189S-195S.
PMID: 6532482 [PubMed - indexed for MEDLINE]

47: Young JH, VandenBurg MJ, Isitt VL, Currie WJ.
Comparison of a fixed ratio combination of hydrochlorothiazide, amiloride and
timolol ('Moducren') given once versus twice daily in mild to moderate
Pharmatherapeutica. 1984;4(1):64-8.
PMID: 6504947 [PubMed - indexed for MEDLINE]

48: Deaney NB, Vogel R, Vandenburg MJ, Currie WJ.
Norfloxacin in acute urinary tract infections.
Practitioner. 1984 Jan;228(1387):111-7. No abstract available.
PMID: 6229726 [PubMed - indexed for MEDLINE]

49: VandenBurg MJ, Evans SJ, Cooper WD, Bradshaw F, Currie WJ.
Is the feeling of cold extremities experienced by hypertensive patients due to
their disease or their treatment?
Eur J Clin Pharmacol. 1984;27(1):47-9.
PMID: 6149129 [PubMed - indexed for MEDLINE]

50: VandenBurg MJ, Robinson PJ, Cooper WD, Currie WJ.
The effects of enalapril and propranolol on beta-endorphin-like
radioimmunoreactivity in hypertensive patients.
Clin Exp Hypertens A. 1984;6(10-11):2069-72. No abstract available.
PMID: 6099778 [PubMed - indexed for MEDLINE]

51: Wilkins MR, Kendall MJ, VandenBurg MJ, Currie WJ.
Is diuretic-induced hypokalaemia clinically important?
J Clin Hosp Pharm. 1983 Dec;8(4):367-71. No abstract available.
PMID: 6662973 [PubMed - indexed for MEDLINE]

52: Vandenburg MJ, Sharman VL, Wright P, Drew PJ, Barnes JN.
Hydralazine and prazosin in the treatment of hypertension.
Br J Clin Pharmacol. 1983 Nov;16(5):537-42.
PMID: 6357257 [PubMed - indexed for MEDLINE]

53: Cooper WD, Currie WJ, Vandenburg MJ.
The influence of physicians' instructions on the outcome of antihypertensive
Br J Clin Pract. 1983 Mar;37(3):99-103. No abstract available.
PMID: 6882631 [PubMed - indexed for MEDLINE]

54: Williams P, Williams P, Currie WJ, VandenBurg MJ.
A double-blind comparison of 'Osmosin', benoxaprofen and placebo in the
treatment of osteoarthritis.
Curr Med Res Opin. 1983;8 Suppl 2:90-8.
PMID: 6342966 [PubMed - indexed for MEDLINE]

55: Young A, Rodriguez C, VandenBurg MJ, Currie WJ.
'Osmosin' in rheumatoid arthritis: interim results.
Curr Med Res Opin. 1983;8 Suppl 2:109-12.
PMID: 6342961 [PubMed - indexed for MEDLINE]

56: Vandenburg MJ, Holly JM, Goodwin FJ, Sharman VL, Marsh FP.
The effect of captopril and propranolol on the responses to posture and
isometric exercise in patients with essential hypertension.
Eur J Clin Pharmacol. 1983;25(6):721-8.
PMID: 6319152 [PubMed - indexed for MEDLINE]

57: Vandenburg MJ.
The acute and chronic effect of oxprenolol and propranolol on peripheral blood
flow in hypertensive patients.
Br J Clin Pharmacol. 1982 Nov;14(5):733-7.
PMID: 7138753 [PubMed - indexed for MEDLINE]

58: Cooper WD, VandenBurg MJ.
Can drugs prevent recurrent myocardial infarction?
J Clin Hosp Pharm. 1982 Sep;7(3):209-12. No abstract available.
PMID: 6129264 [PubMed - indexed for MEDLINE]

59: Vandenburg MJ, Wright P, Holmes J, Rogers HJ, Ahmad RA.
The hypotensive response to hydralazine, in triple therapy, is not related to
acetylator phenotype.
Br J Clin Pharmacol. 1982 May;13(5):747-50. No abstract available.
PMID: 7082547 [PubMed - indexed for MEDLINE]

60: Holly JM, Goodwin FJ, Evans SJ, VandenBurg MJ, Ledingham JM.
Re-analysis of data in two Lancet papers on the effect of dietary sodium and
potassium on blood pressure.
Lancet. 1981 Dec 19-26;2(8260-61):1384-7. No abstract available.
PMID: 6118759 [PubMed - indexed for MEDLINE]

61: Ahmad RA, Rogers HJ, Vandenburg M, Wright P.
Effects of concurrent administration of other substrates of N-acetyltransferase
on dapsone acetylation.
Br J Clin Pharmacol. 1981 Jul;12(1):83-6. No abstract available.
PMID: 7248142 [PubMed - indexed for MEDLINE]

62: Cunningham J, Vandenburg MJ, Holly JM, Goodwin FJ.
Impaired response of plasma renin activity to tilting after renal
Clin Sci (Lond). 1981 Jul;61(1):69-73.
PMID: 7018812 [PubMed - indexed for MEDLINE]

63: Vandenburg MJ, Conlon C, Ledingham JM.
A comparison of the effects of propranolol and oxprenolol on forearm blood flow
and skin temperature.
Br J Clin Pharmacol. 1981 May;11(5):485-90.
PMID: 7272160 [PubMed - indexed for MEDLINE]

64: VandenBurg MJ, Sharman VL, Morton JJ, Williams GH, Marsh FP.
Hormonal and blood pressure changes during converting enzyme inhibition by
Postgrad Med J. 1981 May;57(667):283-8.
PMID: 6170971 [PubMed - indexed for MEDLINE]

65: Parfrey PS, Condon K, Wright P, Vandenburg MJ, Holly JM, Goodwin FJ, Evans
SJ, Ledingham JM.

Blood pressure and hormonal changes following alteration in dietary sodium and
potassium in young men with and without a familial predisposition to
Lancet. 1981 Jan 17;1(8212):113-7.
PMID: 6109798 [PubMed - indexed for MEDLINE]

66: Parfrey PS, Vandenburg MJ, Wright P, Holly JM, Goodwin FJ, Evans SJ,
Ledingham JM.

Blood pressure and hormonal changes following alteration in dietary sodium and
potassium in mild essential hypertension.
Lancet. 1981 Jan 10;1(8211):59-63. No abstract available.
PMID: 6109118 [PubMed - indexed for MEDLINE]

67: Vandenburg M, Parfrey P, Wright P, Lazda E.
Hepatitis associated with captopril treatment.
Br J Clin Pharmacol. 1981 Jan;11(1):105-6. No abstract available.
PMID: 7011347 [PubMed - indexed for MEDLINE]

68: Parfrey PS, Clement M, Vandenburg MJ, Wright P.
Captopril-induced pemphigus.
Br Med J. 1980 Jul 19;281(6234):194. No abstract available.
PMID: 6996785 [PubMed - indexed for MEDLINE]

69: Rae SA, Vandenburg M, Scholtz CL.
Aortic regurgitation and false aortic aneurysm formation in Behcet's disease.
Postgrad Med J. 1980 Jun;56(656):438-9.
PMID: 7413548 [PubMed - indexed for MEDLINE]

70: Vandenburg MJ, Sharman VL, Marsh FP, Rucinska EJ.
Prolonged treatment of high-renin hypertension with a converting enzyme
Br Med J. 1978 Sep 23;2(6141):866. No abstract available.
PMID: 709099 [PubMed - indexed for MEDLINE]

71: Swash M, Schwartz MS, Vandenburg MJ, Pollock DJ.
Myopathy in Whipple's disease.
Gut. 1977 Oct;18(10):800-4.
PMID: 73496 [PubMed - indexed for MEDLINE]


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Drug Development Programs Planned and Managed by Dr M J VandenBurg (PHASE IIA)


Go/No-go studies for:

A potassium channel activator
Calcium sensitiser
Insulin sensitiser
Anti-rheumatic disease modifier
Obsessive compulsive disorder
H2 antagonist
Many anti infectives
Drugs for hypertension
- Heart failure
- Angina and Arrhythmias

Oral inotropes for CHF
Anti nausea drugs
Drugs for pain
Peripheral vascular disease
Homeopathic for flu
Irritable Bowel Syndrome
Alcohol abuse


Phase III programs for:

Three converting enzyme inhibitors
H2 antagonist
Anti-cancer agents
Many anti-infectives
Aids therapy
Potassium channel activator
Alcohol Addiction
Non-steroidial anti-inflammatory drugs
Parkinson's therapy
Vaccines for Hepatitis B
Wound dressings
Raised IOP


Phase IV programs:

Anti hypertensives
H2 antagonist
Non-steroidial anti-inflammatory drugs
Anti-Bleeding Compounds.


Analysis, Study Reports, Safety and Efficacy Summaries, IND safety updates, NDA Filings and European
Clinical Expert Report for:


* Anti-arrhythmic
* Hypnotic
* Anti-epileptic
* Anti-Infective


Complete European submissions for:


* Anti-hypertensives
* Anaesthetics
* Drugs for heart failure,
* Angina
* Anti-cancer agents
* Anti-anaemic products
* Drugs for bladder outflow
* Anti-platelet agents
* Antihistamines


Safety reports for many drugs relating to:

Cardiac, Hepatic, Renal and Photo Toxic Safety Issues as well as safety in stomach and colon

Only the major programs have been listed, single studies and consultancy projects have been carried out in
almost all therapeutic areas as well as some niche areas such as:

* Cachexia in Aids
* Gene Therapy
* Autologous Transplantation and transfusion
* Blood substitutes
* Wound Growth Modifiers
* Anti oxidant in cardio vascular disease
* Alzheimer's
* Hepatitis A and B
* Anti-fungal
* Syjrogens Syndrome
* Anti-thrombotics

Copyright © 2009 Dr. Malcolm VandenBurg - Web Design by Top Click Media - All Rights Reserved.